If your computer is equipped with Bluetooth wireless and/or a Wi-Fi (AirPort) card, these may need to be disabled for Pro Tools to work correctly. Un-check the box for ‘Enable Power Nap'.Un-check the box for 'Put hard disks to sleep when possible'.Otherwise, check the box that says 'Prevent computer from sleeping automatically when the display is off.'.If present, set the 'Computer sleep' slider to 'Never'.Do one of the following (available option depends on your computer model).This optimization will free up system resources as well as prevent the computer from going to sleep or standby mode which can cause audio dropouts with Pro Tools software and hardware. Click on the Apple menu in the upper left corner of your screen.To access System Preferences in OS X, do the following: Deleting Pro Tools Preference, Workspace, and WaveCache files.
For best possible performance, it is recommended that you do the following: Pro Tools can be affected by system settings and other software and hardware installed on your computer. Mac Guide - Mac OS X 10.12 Sierra Optimizations and Troubleshooting